CLN Wiki · Deep Systems
Anti-inflammatory Prostaglandins
The Bio-Decision Engine
Prostaglandins are not "good" or "bad" molecules; they are short-lived local hormones that act as system status signals. Your diet and stress levels act as the input that determines which signal is sent.
01/The Master Logic
System Architecture
. Cell membrane lipid composition (Omega-3 vs
Omega-6 ratio)
-> Enzymatic processing (COX-1, COX-2)
-> Prostaglandin Synthesis
= Health = Homeostasis between inflammatory
"fire" and resolution "water"
02/The PGE Series Breakdown
+ PGE1 (from DGLA): The
primary suppressor of chronic inflammation.
* Action: Dilates blood vessels, reduces
platelet stickiness.
+ PGE3 (from EPA): The
competition-based buffer.
* Action: Weakly inflammatory, but displaces
the dangerous PGE2.
! PGE2 (from AA): The
pro-inflammatory driver.
- Necessary for: Acute injury response,
fever.
! Chronic Excess: Linked to Brain Fog,
Depression, and Memory Decay.
03/Cognitive Relevance
. Neuroinflammation is the "invisible wall"
that slows down saccadic processing and memory
recall.
. PGE1/PGE3 promote Resolution
— the active process of turning off the immune response
in the brain.
04/Strategic Optimization
+ Increase GLA intake to favor PGE1
production.
+ Maintain high EPA levels to suppress PGE2 via
PGE3 competition.
! Avoid high refined sugar: Insulin shifts the
DGLA path away from PGE1 and into PGE2.