01/Definition Term

= GLA — a triple-unsaturated fatty acid of the Omega-6 family

= unlike AA (Arachidonic Acid), GLA is predominantly anti-inflammatory

02/Metabolic Pathway Mechanism

. Step 1: Dietary GLA intake

. Step 2: Rapid conversion to DGLA (Dihomo-gamma-linolenic acid)

. Step 3: Conversion to PGE1 (Prostaglandin E1)

* PGE1 = potent vasodilator + anti-inflammatory signal

! D6D Enzyme Bottleneck: the body's ability to make GLA from Linoleic Acid drops with age and stress

03/Cognitive Role Brain

+ Reduces neuroinflammation: prevents "Brain Fog" by lowering inflammatory cytokines

+ Blood-Brain Barrier support: PGE1 helps maintain microcirculation

+ Synergy with EPA: prevents DGLA from turning into pro-inflammatory Arachidonic Acid

04/Sources Practical

. Borage Oil (20-25%) — highest density source

. Evening Primrose Oil (8-10%)

. Black Currant Seed Oil (15-17%)

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